What are CD34+stem cells & MSCs?

These adult stem cells harvested or derived from adult tissues, blood, etc., after birth, can be derived from several tissues, including but not limited to bone marrow and umbilical cord blood.

The stem cells used are either autologous & allogeneic:

• Autologous means the source of the stem cells is the patient,
• Allogeneic means the source of stem cells comes from another person, not the patient to be treated.

CD34+ stem cells:

• CD34+ stem cells are blood-forming or hematopoietic stem cells, which can also form blood vessels and other types of cells in the body.
• Autologous CD34+ stem cells can be harvested directly from the bone marrow or blood after mobilizing or inducing them to move from the bone marrow into the blood using well-established clinical protocols.
• Purified CD34+ stem cell populations are produced from these collections in a hospital cell therapy laboratory.
• For preclinical validation studies, CD34+ stem cells will be purchased from commercial stem cell suppliers for validation and safety studies.
• For clinical trials, CD34+ stem cells will be purified from the patient’s bone marrow and used in compliance with standard clinical treatment protocols or custom-manufactured in accordance with GMP regulations approved by the FDA.

Mesenchymal stem cells (MSCs):

• MSCs are non-hematopoietic adult stem cells isolated from different sources that can differentiate into other types of cells in the body. These sources include but are not limited to, bone marrow, fat (adipose tissue), umbilical cord tissue (Wharton's Jelly), placenta, or amniotic fluid (the fluid surrounding a fetus).
• MSCs can be allogeneic (from unrelated donors).
• Allogeneic MSCs can be purchased from stem cell manufacturing companies.
• Autologous MSCs derived and grown from the patient's tissues may not be required for heart repair therapy. However, if needed, they can be produced in a hospital cell therapy laboratory or custom-manufactured by a stem cell company in accordance with GMP regulations approved by the FDA.